In addition, as other checkpoints are testing, further improvements in pathologic responses and clinical outcomes are expected. PubMedGoogle Scholar, Yajnik, S. (2019). Head and Neck Cancer | NEJM Ann Oncol (2018) 29(8):16302. Furthermore, the one-year relapse rate in high-risk patients was 16.7%, which was lower than historical data. In a landmark trial, a . The landmark Docetaxel-Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DECIDE) trial randomized 285 patients between 2004 and 2009 to concurrent chemoradiation plus or minus induction chemotherapy. Overall, only 15-20% of patients ultimately benefit from anti-PD-1 in these studies highlighting the need for improving efficacy of CPIs for HNSCC treatment. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. Intriguingly, TMB was significantly higher among HPV-/EBV- responders and correlated with OS, but not high in HPV+/EBV+ responders who didnt show any correlation between TMB and OS (52). Cancer Discov (2016) 6(12):138299. Bauml J, Seiwert TY, Pfister DG, Worden F, Liu SV, Gilbert J, et al. Received: 18 June 2021; Accepted: 19 August 2021;Published: 06 September 2021. SM is Chief of the Department Hematology-Oncology at the Azienda Ospedaliera Pugliese-Ciaccio Catanzaro, Italy. In neoadjuvant breast cancer, the I-SPY 1 and 2 trials have successfully matched treatment and biomarkers, using adaptive randomised designs [43, 44]. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Manage cookies/Do not sell my data we use in the preference centre. These included oral mucositis and one patient with autoimmune diabetes (68) and there were no surgical delays. doi: 10.1056/NEJMoa032646, 6. To determine the survival benefit of IC using docetaxel plus cisplatin and fluorouracil (TPF) regimen followed by CCRT, two-phase III randomized trials were completed: the PARADIGM trial reported in 2013 (19) and DeCIDE trial reported in 2014 (20). By contrast, neoadjuvant immunotherapy is fundamentally distinct as it targets the host immune system to attack tumor cells in a durable fashion. 2013;10(5):27788. 2014;371(3):21323. Another meta-analysis showed that HPV positive HNSCC patients display significant improved outcomes with PD-1/PD-L1 axis blockage treatment compared to HPV negative HNSCC patients (46). The goals of induction chemotherapy are to achieve rapid tumor responses in particular with large volume disease and to chemo-select patients prior for definitive (chemo)radiotherapy or surgery.
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