Some 60,000 years ago, a wave of early humans ventured out of Africa, spreading to every other corner of the world. Nature (Nature) [2] Neanderthal genetics DNA This would be an interesting thing to follow up on.. Several studies suggest that Neanderthals may have harbored sequences that were deleterious for modern Please be respectful of copyright. While non-African populations today come from a wave of humans who left Africa roughly 60,000 years ago, they werent the first to venture outside the continent. and Rieux et al. Previous studies have found only about 0.02 percent of Neanderthal DNA in modern African genomes. Therefore, when modern humans left again during the peak of migration, Neanderthals already had a little Homo sapiens DNA in their genome. ABOVE: A Neanderthal skullWIKIMEDIA, AQUILAGIB. For general inquiries, please use our contact form. Intriguingly, the new method also reveals slightly more Neanderthal DNA in modern Europeans that was previously overlooked, narrowing the baffling 20 percent gap once thought to exist between Neanderthal ancestry in Europeans and East Asians. Clearly theres no one-way bridge there.. Their sister group, the Denisovans, spread through Asia. While the new method isnt super sensitive to these types of population differences, Akey adds, its still possible that these unknown Neanderthals had a slightly different contribution. Hed like to see it applied to an even greater number of modern African populations to get a more detailed picture of how this ancestry varies across the array of people throughout the continent. To approach a question 400 million years in the making, researchers turned to mudskippers, blinking fish that live partially out of water. while Europeans showed clustering in functional groups related to the lipid catabolic process. Now a study, published this week in Cell, presents a striking find: Modern African populations carry more snippets of Neanderthal DNA than once thought, about a third of the amount the team identified for Europeans and Asians. All rights reserved. Claire Jordan. Asians also carry additional Denisovan DNA, up to 6 percent in Melanesians. While studies have generally supported the hypothesis that modern human genomes shed any untoward traces of Neanderthal DNA, how this process occurred was unclear. Neanderthal variants affect the risk of developing several diseases, including lupus, biliary cirrhosis, Crohn's disease, type 2 diabetes, and SARS-CoV-2. The results suggest that modern Africans carry an average of 17 million Neanderthal base pairs, which is about a third of the amount the team found in Europeans and Asians. The straightforward answer would be that Neanderthals ventured into the continent. However, in 2016 researchers published a new set of Neanderthal DNA sequences from Altai Cave in Siberia, as well as from Spain and Croatia, that show evidence of human-Neanderthal interbreeding as far back as 100,000 years ago -- farther back than many previous estimates of humans migration out of Africa (Kuhlwilm et al., 2016).
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